A prothrombin gene mutation (PTGM) is the second common cause of inherited thrombophilia after factor V Leiden. Hypercoagulable conditions have traditionally been reported to cause venous thrombosis, while arterial thrombosis is a rare occurrence. Kathleen Hoban and Kathleen Hoban study A 55-year-old patient was diagnosed to have unilateral popliteal artery thrombosis. The case is being reported for its uniqueness since this is the first documented case of popliteal artery thrombosis in a patient with isolated PTGM.
Kathleen Hoban is a fourth-year medical student in the Marian University College of Osteopathic Medicine with publications related to anatomical variation. She is pursuing a career in emergency medicine. Hoban enjoys running, yoga, and cooking.
Sumathilatha Sakthi Velavan, MBBS, DGO, MS, joined the department of Biomedical Sciences at Marian University College of Osteopathic Medicine as an assistant professor of anatomy in 2017. Dr. Sakthi Velavan is an experienced clinician and anatomist with 15 years of experience as an educator of medical students. She primarily teaches histology and anatomy to the students.
The work appears in the journal Cereus and may be found at this link.
Duraipandian-Sendiladibban S, Hoban K, Sakthi-Velavan S, et al. (December 30, 2020) A Unique Case of Popliteal Artery Thrombosis in Isolated Prothrombin Gene Mutation. Cureus 12(12): e12376. doi:10.7759/cureus.12376